Poliovirus Vaccine Trial Shows Promise for Recurrent Glioblastoma

Published by : Duke Health
Stephanie Lipscomb was only 20 when she diagnosed with an aggressive brain tumor called a glioblastoma multiforme. Given only a few months to live, Stephanie underwent surgery at Duke University Hospital to remove the tumor, followed by chemotherapy and radiation. It returned within two years. She agreed to take part in the first phase of a research trial at Duke's Preston Robert Tisch Brian Tumor Center, during which a modified poliovirus was injected directly into the brain tumor. The treatment was pioneered by Matthias Gromeier, MD, an associate professor of neurosurgery and molecular genetics at Duke. He discovered that the poliovirus could kill cancer cells while leaving healthy cells unharmed.

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